Research Overview

Our research focuses on the mechanisms of spermatogenesis and germline-mediated epigenetic inheritance. In particular, we are interested in the epigenetic and posttranscriptional regulation of gene expression in meiotic and post-meiotic male germ cells, and the role of sperm-borne RNAs in transmitting information about acquired traits and conditions to offspring. We use mainly mouse as a model, but we are also actively involved in cohort studies to translate our results to humans. Altogether, our research provides important novel insights into causes and mechanisms of male infertility, and the intriguing potential contribution of father’s preconception lifestyle and environmental exposures to offspring health.